A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2626783
The present invention relates to antibodies that -differentially -recognize- - multi- dimensional conformations- of- A.beta.- derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid .beta. 1-42.
L'invention concerne des anticorps de reconnaissance différentielle de conformations multidimensionnelles de ligands diffusibles dérivés de l'amyloïde bêta, également désignés ADDL. Ces anticorps peuvent distinguer entre des extraits de cerveau humain atteints de la maladie d'Alzheimer et des témoins et sont utiles dans des procédés de détection des ADDL et le diagnostic de ladite maladie. Ces anticorps permettent le blocage de la liaison des ADDL aux neurones, l'assemblage des ADDL et la phosphorylation de Tau et sont utiles dans des procédés pour la prévention et le traitement de maladies associées à des oligomères solubles de l'amyloïde bêta 1-42.
An Zhiqiang
Kinney Gene
Strohl William R.
Borden Ladner Gervais Llp
Merck & Co. Inc.
LandOfFree
Anti-addl monoclonal antibody and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-addl monoclonal antibody and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-addl monoclonal antibody and use thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1634365