C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61P 35/00 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2526647
Monoclonal antibodies that specifically bind to the tetrameric form of the alpha-folate receptor and not the monomeric form are provided. The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alphafolate receptor ("FR-a"), such as ovarian cancer. Hybridoma cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of detecting and treating cancer using the antibodies, derivatives and fragments also are provided.
L'invention concerne des anticorps monoclonaux qui se lient de manière spécifique à la forme tétramère, et non monomère, du récepteur de folate alpha. Ces anticorps servent à traiter certains cancers, en particulier des cancers accompagnés d'une expression accrue des cellules de surface du récepteur de folate alpha ("FR-.alpha."), par exemple le cancer des ovaires. Cette invention concerne également des cellules d'hybridome qui expriment lesdits anticorps monoclonaux, des dérivés de ces anticorps, tels que des anticorps monoclonaux chimériques et humanisés, des fragments de ces anticorps, des cellules mammaliennes exprimant les anticorps monoclonaux, leurs dérivés et fragments. L'invention se rapporte en outre à des procédés permettant de détecter et de traiter un cancer au moyen desdits anticorps, dérivés et fragments.
Grasso Luigi
Nicolaides Nicholas C.
Sass Philip M.
Gowling Lafleur Henderson Llp
Morphotek Inc.
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