C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) C07K 14/78 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2629715
The invention relates to anti-.alpha.2 integrin antibodies and their uses. humanized antibodies are disclosed that bind to the I domain of .alpha.2 integrin and inhibit the interaction of .alpha.2.beta.1 integrin with collagen. Also disclosed are therapeutic uses of anti-.alpha.2 integrin antibodies in treating .alpha.2.beta.1-mediated disorders, including anti-.alpha.2 integrin antibodie s that bind to .alpha.2 integrin without activating platelets. Image
La présente invention a trait à des anticorps anti-integrine a2 et leurs utilisations. L'invention a trait à des anticorps humanisés de liaison au domaine I et l'intégrine a2 et d'inhibition de l'interaction de l'intégrine a2ß1 avec le collagène. L'invention a également trait aux utilisations thérapeutiques d'anticorps anti-integrine a2 dans le traitement de troubles liés à l'a2ß1, y compris des anticorps anti-integrine a2 de liaison à l'intégrine a2 sans activation de plaquettes.
Bernard Mark
Lazarides Elias
Woods Catherine
Glenmark Pharmaceuticals S.a.
Goudreau Gage Dubuc
LandOfFree
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