C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2593777
An anti-mouse .alpha.9 integrin antibody, an anti-human .alpha.9 integrin antibody, a hybridoma cell producing any of the antibodies, a method of producing any of the antibodies and the hybridoma cell, and a pharmaceutical composition comprising any of the antibodies are provided. The anti-.alpha.9 integrin antibody exerts a therapeutic effect on cancer, for example proliferation and metastasis of a cancer cell, and an inflammatory disease, for example rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease and the like by inhibiting the .alpha.9 integrin function.
L'invention porte sur un anticorps d'intégrine anti-souris .alpha.9, sur un anticorps d'intégrine anti-humain .alpha.9, et sur une cellule d'hybridome fabriquant n'importe lequel de ces anticorps, sur un procédé de fabrication de n'importe lequel de ces anticorps et de la cellule d'hybridome, ainsi que sur une composition pharmaceutique contenant n'importe lequel de ces anticorps. Cet anticorps d'intégrine anti-.alpha.9 possède un effet thérapeutique sur le cancer, par exemple la prolifération et la métastase d'une cellule cancéreuse, et sur des maladies inflammatoires, par exemple l'arthrite rhumatoïde, l'arthrose, l'hépatite, l'asthme bronchique, la fibrose, le diabète, l'artériosclérose, la sclérose en plaques, le granulome, et les maladies inflammatoires des intestins (la colite ulcéreuse et la maladie de Crohn), et les maladies auto-immunes et similaires par inhibition de la fonction d'intégrine .alpha.9.
Kanayama Masashi
Kon Shigeyuki
Kurotaki Daisuke
Uede Toshimitsu
Fetherstonhaugh & Co.
Gene Techno Science Co. Ltd.
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