Anti-alphabeta3 humanized monoclonal antibodies

Details Anti-alphabeta3 humanized monoclonal antibodies Anti-alphabeta3 humanized monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/20 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2284518

This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to the vitronectin .alpha.v.beta.3 receptor and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of .alpha.v.beta.3-mediated disorders, such as restenosis, in human patients.

La présente invention concerne de nouveaux anticorps humanisés et d'autres anticorps obtenus par recombinaison ou manipulation, ou des anticorps monoclonaux contre le récepteur .alpha.¿v?.beta.¿3? de vitronectine et contre les gènes le codant. Ces anticorps s'utilisent dans le traitement thérapeutique et/ou prophylactique de troubles induits par .alpha.¿v?.beta.¿3?, tels que la resténose chez des patients humains.

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