Anti-amyloid beta antibodies and their use

Details Anti-amyloid beta antibodies and their use Anti-amyloid beta antibodies and their use

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2477012

The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

L'invention concerne des molécules d'anticorps capables de reconnaître de manière spécifique deux régions du peptide .beta.-A4, la première région comprenant la séquence d'aminoacide AEFRHDSGY, telle qu'indiquée dans SEQ ID NO :1, ou un de ses fragments, la seconde région comprenant la séquence d'aminoacide VHHQKLVFFAEDVG, telle qu'indiquée dans SEQ ID NO :2, ou un de ses fragments. L'invention concerne, de plus, des molécules d'acides nucléiques codant lesdites molécules d'anticorps, des vecteurs et des hôtes comprenant lesdites molécules d'acides nucléiques. L'invention concerne également des compositions, de préférence des compositions pharmaceutiques ou diagnostiques, comprenant les composés de l'invention ainsi que des utilisations spécifiques desdites molécules d'anticorps, des molécules d'acides nucléiques, des vecteurs et des hôtes de l'invention.

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