Anti-androgen compounds

Details Anti-androgen compounds Anti-androgen compounds

C - Chemistry, Metallurgy

07

C

167/179, 260/30,

C07C 33/00 (2006.01) A61K 31/045 (2006.01) A61K 31/05 (2006.01) A61K 31/12 (2006.01) A61K 31/22 (2006.01) A61K 31/56 (2006.01) C07C 39/17 (2006.01) C07C 45/51 (2006.01) C07C 49/657 (2006.01) C07C 49/665 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 49/792 (2006.01) C07J 1/00 (2006.01) C07J 63/00 (2006.01)

Patent

CA 1338667

Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities. Preferred derivatives include 1-[2-(9,10- dihydrophenanthryl)]-1-ethanol; 6,7,16,17-tetrahydro-15H- cyclopenta[a]-phenanthren-17-ol; 1-[2-(9(or 10)-methyl- 9,10-dihydrophenanthryl)]-1-ethanol; 2-hydroxy-9,10- dihydrophenanthrene; 6,7,16,17-tetrahydro-15H- cyclopenta[a]pehanthren-17-one; 4'-oxo-7,8-cyclohexeno- 9,10-dihydrophenanthren-1-ol; and 4'-oxo-7,8-cyclohexeno- phenanthren-1-ol. Also provided by the invention are the corresponding derivatives wherein a free hydroxyl group has been replaced with an acetate or a propionate moiety.

614576

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