Anti-androgenic [3,2-c]pyrazole and [3,2-d]triazole steroids

Details Anti-androgenic [3,2-c]pyrazole and [3,2-d]triazole steroids Anti-androgenic [3,2-c]pyrazole and [3,2-d]triazole steroids

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2086678

ABSTRACT OF THE DISCLOSURE The invention discloses [3,2-c]pyrazole and [3,2-d] triazole steroids of general formula (I) wherein X stands for the CH group or a nitrogen atom, R1 stands for an alkylsulfonyl group R-SO2 and also, if X is the CH group, for an acyl group R-CO-, R in each case denoting an alkyl group with 1 to 3 carbon atoms, and the other substituents have the meaning given in the description, and a process for producing them. The new compounds exhibit a marked anti-androgenic activity together with peripheral selectivity and can be used in the manufacture of drugs.

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