Anti-angiogenesis combination therapies comprising...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/502 (2006.01) A61K 31/501 (2006.01) A61K 31/5025 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2471314

The invention relates generally to the use of certain substituted fused or unfused pyridazine or pyridine derivatives which are KDR inhibitors in combination with other chemotherapeutic agents for use in treatment of diseases associated with abnormal angiogenesis and/or hyperpermeability and/or hyperproliferative diseases, such as cancer.

L'invention concerne, de façon générale, l'utilisation de certains dérivés de pyridazine ou pyridine substitués condensés ou non condensés, qui sont des inhibiteurs de KDR, en association avec d'autres agents chimiothérapeutiques dans le traitement de maladies associées à l'angiogenèse anormale et/ou l'hyperméabilité et/ou les maladies hyperproliférantes, telles que le cancer.

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