Anti-angiogenic cellular agent for cancer therapy

Details Anti-angiogenic cellular agent for cancer therapy Anti-angiogenic cellular agent for cancer therapy

A - Human Necessities

61

K

A61K 35/14 (2006.01) C12N 5/071 (2010.01) C12N 5/078 (2010.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2391434

The invention provides cytokine induced killer (CIK) cell populations and methods of using CIK cells to treat cellular proliferative disorders. CIK cells generated in vitro include both bulk cultures and clones. Individual CIK cell clones display distinct but overlapping lytic specificities for tumor cells and endothelial cells in vitro. When injected in vivo, bulk CIK cell cultures selectively attack tumor tissue. CIK cells can be used to treat a variety of cellular proliferative disorders, including early and late stage cancers as well as hematopoietic cell and solid tissue tumors.

L'invention concerne des populations de cellules K induites par des cytokines (CIK) ainsi que des méthodes d'utilisation de ces cellules CIK pour traiter des troubles prolifératifs. Les cellules CIK générées in vitro comprennent des cultures en massif et des clones. Les clones individuels de cellules CIK présentent des spécificités lytiques distinctes mais imbriquées pour les cellules tumorales et les cellules endothéliales in vitro. Lorsqu'elles sont injectées in vivo, les cultures en massif de cellules CIK attaquent sélectivement le tissu tumoral. Les cellules CIK peuvent servir à traiter plusieurs troubles prolifératifs cellulaires, notamment des cancers en phase précoce ou terminale ainsi que des tumeurs des cellules hématopoïétiques et des tumeurs solides du tissu.

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