Anti-angiogenic methods and compositions

Details Anti-angiogenic methods and compositions Anti-angiogenic methods and compositions

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01)

Patent

CA 2599004

Provided herein are zinc finger proteins that bind to particular target sites in the pigment epithelium-derived protein (PEDF) gene and regulate its expression. These zinc finger proteins are used in methods and compositions for regulating angiogenesis. Also disclosed are zinc finger proteins which bind and regulate the expression of the granulocyte-macrophage colony stimulating factor (GM-CSF) gene and their use in methods and compositions that treat tumors.

L'invention concerne des méthodes et des compositions destinées au traitement d'états nécessitant l'inhibition de l'angiogénèse. Parmi de tels états, on peut citer les états caractérisés par la néovascularisation, tels que des rétinopathies, la dégénérescence maculaire et diverses malignités.

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