Anti-angiogenic peptides and methods of use thereof

Details Anti-angiogenic peptides and methods of use thereof Anti-angiogenic peptides and methods of use thereof

A - Human Necessities

61

K

A61K 38/04 (2006.01)

Patent

CA 2575622

Anti-angiogenic peptides that inhibit VEGF-mediated activation or proliferation of endothelial cells are disclosed. Such peptides may be used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR). Such peptides may also be used to inhibit VEGF-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases and skin disorders.

La présente invention a trait à des peptides anti-angiogènes inhibiteurs d'activation ou de prolifération de cellules endothéliales induite par le facteur de croissance endothéliale (VEGF). De tels peptides peuvent être utilisés pour l'inhibition du facteur VEGF au récepteur 2 du facteur VEGF (aussi connu comme le récepteur du domaine kinase ou KDR). De tels peptides peuvent également utilisés pour l'inhibition d'activation de cellules endothéliales induite par le facteur VEGF dans des maladies associées à l'angiogenèse telles que le cancer, les maladies inflammatoires, les maladies oculaires et les maladies de la peau.

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