Anti-angiogenic peptides and methods of use thereof

Details Anti-angiogenic peptides and methods of use thereof Anti-angiogenic peptides and methods of use thereof

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2583399

Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides maybe used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.

L'invention concerne des peptides anti-angiogéniques qui inhibent l'activation ou la prolifération de cellules endothéliales. Ces peptides peuvent servir à inhiber la fixation de VEGF au récepteur VEGFR2 (également appelé récepteur du domaine kinase ou KDR) et la fixation de bFGF à son récepteur. Lesdits peptides peuvent aussi servir à inhiber VEGF, bFGF ou l'activation des intégrines de cellules endothéliales dans des maladies associées à l'angiogenèse telles que le cancer, la leucémie, le myélome multiple, les maladies inflammatoires, les maladies des yeux et les troubles cutanés.

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