Anti-apoptotic protein antibodies

Details Anti-apoptotic protein antibodies Anti-apoptotic protein antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C07K 17/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/48 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2625951

Single-domain antibodies that bind pro-apoptotic proteins Bax and caspase-3 are identified and isolated. These single-domain antibodies may be used to modulate the activity of Bax and caspase-3, thereby modulating the symptoms and steps of oxidative stress and/or cell apoptosis, including Bax dimerization, mitochondrial permeabilization and the release of apoptotic proteins.

Selon cette invention, des anticorps à domaine unique, lesquels se lient à des protéines pro-apoptotiques Bax et caspase-3 sont identifiés et isolés. Ces anticorps à domaine unique peuvent être utilisés pour moduler l'activité de Bax et caspase-3, ce qui permet de moduler les symptômes et les étapes de stress oxydatif et/ou d'apoptose cellulaire, notamment la dimérisation de Bax, la perméabilisation mitochondriale et ce qui permet également de moduler la libération de protéines apoptotiques.

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