Anti-arrhythmia agents, methods of their use, methods of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/635 (2006.01) A61K 31/05 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61K 31/365 (2006.01) A61K 31/4164 (2006.01) A61P 9/06 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2733930

The disclosure describes an animal model for simulating cardiac arrhythmia. Methods of discovering new anti-arrhythmia drugs using the model are described. Novel anti-arrhythmia agents are provided, as are pharmaceutical compositions made from the agents. Methods of inhibiting spontaneous mechanical activity in myocardially-derived biological systems, and methods of treating and preventing cardiac arrhythmia based on novel anti- arrhythmia agents are described. Kits for performing the above methods are also described.

L'invention concerne un modèle animal pour simuler une arythmie cardiaque. Des procédés de découverte de nouveaux médicaments anti-arythmie utilisant le modèle sont décrits. De nouveaux agents anti-arythmie sont fournis, comme le sont des compositions pharmaceutiques réalisées à partir des agents. Des procédés d'inhibition d'activité mécanique spontanée dans des systèmes biologiques à dérivation myocardique, et des procédés de traitement et de prévention d'arythmie cardiaque basés sur de nouveaux agents anti-arythmie sont décrits. Des kits pour mettre en uvre les procédés ci-dessus sont également décrits.

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