C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/22, 260/54,
C07J 41/00 (2006.01)
Patent
CA 1136122
ABSTRACT OF THE DISCLOSURE New and pharmacologically useful 3.beta.-amino-2.beta.-hydroxy steroids of the androtane, oestrane and pregnane series are described of the formula: Image and pharmaceutically acceptable non-toxic acid-adition salts of these compounds, wherein: R1 is H, alkyl of one to six carbons or acyl of one to eighteen carbons; R2 is H or acyl of one to eighteen carbons: R3 is H or methyl, Y is selected from the group consisting of D, acetalized O, H(.beta.OR4). R5 (.beta.OR4). H(.beta.COCH3) and H(.beta.CHOR4CH3); R4 is H or acyl of one to eighteen carbons; and R5 is a saturated or unsaturated aliphatic hydro- carbyl of one to four carbons; as well as pharmaceutically acceptable compositions comprising a pharmaceutically effective amount of a compound of the above formula, and a pharmaceuti- cally effective carrier. The novel compounds have anti-arrhythmic properties, have no or minimal and transient haemodynamic effects, have no local anaesthetic properties and do not cause CNS stimulation. The compounds also have prophlactic effect and decrease infarctsize.
336816
Boyd Andrew C.
Savage David S.
Sleigh Thomas
Akzona Incorporated
Swabey Ogilvy Renault
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