Anti-atherosclerotic aryl compounds

Details Anti-atherosclerotic aryl compounds Anti-atherosclerotic aryl compounds

C - Chemistry, Metallurgy

07

C

C07C 275/28 (2006.01) A61K 31/17 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/38 (2006.01) C07C 233/51 (2006.01) C07C 271/40 (2006.01) C07C 275/30 (2006.01) C07C 275/34 (2006.01) C07C 323/44 (2006.01) C07D 333/28 (2006.01)

Patent

CA 2098122

The present invention is concerned with compounds of formula (I) wherein Ar is a mono- or bicyclic aromatic group op- tionally containing one or two heteroatoms independently selected from nitrogen, oxigen and sulphur, said group being optional- ly substituted by one or more atoms or groups independently selected from halogen, vitro, amino, -NRR1 where R and R1 are independently selected from hydrogen, C1-8 alkyl and C1-8 alkanoyl, cyano, carboxyalkoxy, alkoxycarbonylalkoxy, C1-8 al- kyl (including cycloalkyl and cycloalkylalkyl), C1-8 alkoxy (including cycloalkoxy and cycloalkylalkoxy), C1-8 thioalkyl, said alkyl, alkoxy and/or thioalkyl groups) being optionally substituted by one or more halogen atoms, aryl, aryloxy, aralkyl and aralkyloxy, said aryl, aryloxy, aralkyl and/or aralkyloxy group(s) being optionally substituted by one or more atoms or groups independently selected from halogen, alkyl, alkoxy, alkanoyl, hydroxyalkyl, perfluoroalkyl, perfluoroalkoxy, carbox- yalkoxy, alkoxycarbonylalkoxy, and C3-8 polyether groups containing from one to three oxygen atoms; D is -CH2-, -NH-, or -O-; E is (a) or (b); G is hydrogen, C1-12 straight, branched, or cyclic alkyl, or aralkyl, said aralkyl group being optionally substituted by one or more atoms or groups independently selected from halogen, amino, N-(C1-6 alkyl)amino, N,N-di(C1-6 alkyl)amino, C1-6 alkyl and C1-6 alkoxy, or a C3-8 polyether group containing one to three oxygen atoms; J is a bond or C1-6 straight or branched alkylene; n is an integer of from O to 10; R and R1 are as hereinbefore defined; and K is -CH2OH, -CHO, -CONHCH2CONH2, .cndot.CONH(C1-6 alkyl), -OC(C1-4 alkyl)2OCO heteroaryl, - CO2R2 where R2 is hydrogen, C1-8 al- kyl, aryl, heteroaryl, aralkyl, heteroaralkyl, or a C3-8 polyether group containing from one to three oxygen atoms, or -CON- HAr' where Ar' is phenyl optionally substituted by one or more atoms or groups selected from fluorine, nitro, -NRR1 where R and R1 are as hereinbefore defined, C1-6 alkyl and C1-6 alkoxy, said alkyl and/or alkoxy group(s) being optionally substi- tuted at the terminal carbon by -CO2R3 where R3 is C1-6 alkyl; and their physiologically functional derivatives, with pro- cesses for their preparation, with medicaments containing them and with their use as therapeutic agents, particularly in the prophylaxis and treatment of atherosclerosis.

Affiliated with

Also associated with

Rating

Anti-atherosclerotic aryl compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-atherosclerotic aryl compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-atherosclerotic aryl compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1725357