Anti-atherosclerotic diaryl compounds

Details Anti-atherosclerotic diaryl compounds Anti-atherosclerotic diaryl compounds

C - Chemistry, Metallurgy

07

C

167/249, 167/264

C07C 271/42 (2006.01) A61K 31/16 (2006.01) C07C 233/07 (2006.01) C07C 233/11 (2006.01) C07C 271/44 (2006.01) C07C 275/24 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 279/28 (2006.01) C07C 327/44 (2006.01)

Patent

CA 2003395

PA1015FF(ABS) ABSTRACT Anti-atherosclerotic Diaryl Compounds The present invention is concerned with compounds of formula (I) Image (I) wherein m is 0 or 1; W is hydrogen, a C1-16 straight, branched, or cyclic alkyl group, or a C2-16 straight, branched, or cyclic alkenyl or alkynyl group, or Ph(CH2)n- where Ph is phenyl and n is an integer of from 0 to 2, the phenyl group being optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C1-4 alkoxy and C1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen, or R1NHCO- where R1 is hydrogen or a C1-6 alkyl group, or R2CONH- where R2 is hydrogen or a C1-6 alkyl group; X is Image where p is an integer of from 0 to 2, Image WMD/JJ/31st October, 1989. PA1015FF(ABS) Y is -(CH2)q, where q is an integer of from 1 to 3, or -CH=CH- (E or Z); Z is a C1-6 alkyl group optionally substituted by one or more independently selected polar groups; and ring A is optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C1-4 alkoxy and C1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen; provided said compound of formula (I) is not N-(2-[(4-methyl- phenyl)methyl]phenyl)acetamide or .alpha.-(p-tolyl)-o-cresol carbanilate; and salts, solvates and physiologically functional derivatives thereof, processes for the preparation of these compounds, pharmaceutical formulations containing them and their use in medicine. WMD/JJ/31st October, 1989.

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