Anti-atherosclerotic trisubstituted ureas

Details Anti-atherosclerotic trisubstituted ureas Anti-atherosclerotic trisubstituted ureas

C - Chemistry, Metallurgy

07

C

167/265, 260/547

C07C 275/30 (2006.01)

Patent

CA 1239150

ABSTRACT Substituted urea derivatives, and processes for their preparation of the general formula Image are described, in which A is a halo-substituted phenyl group; n is 1 to 5; R1 and R2 are each hydrogen or lower alkyl; and Z is hydrogen, lower alkoxy, halo, or the group (CH2)m-CR3R4-CH3, in which m is 0 to 5; and R3 and R4 are hydrogen or lower alkyl, with the proviso that R1, R2, R3 and R4 cannot all be hydrogen. These compounds find use in heating atherosclerosis, in reducing the cholesterol content of arterial walls, in treating hyperlipidemia, and in inhibiting atherosclerotic lesion development in mammals. The compounds are generally administered combined with a suitable pharmaceutically acceptable carrier, and passes the practical advantage that they may be administered orally as well as by injection.

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