Anti-atherosclerotic trisubstituted ureas and thioureas

C - Chemistry – Metallurgy – 07 – C

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C07C 275/28 (2006.01) C07C 335/16 (2006.01) C07D 317/60 (2006.01)

Patent

CA 1291132

ANTI-ATHEROSCLEROTIC TRISUBSTITUTED UREAS AND THIOUREAS ABSTRACT OF THE DISCLOSURE Trisubstituted ureas and thioureas useful as anti- atherosclerotic agents, compositions thereof and processes for their preparation are disclosed. These compounds are of the general formula: Image wherein X is a substituent selected, for example, from alkyl, alkenyl, alkinyl, alkoxy, alkylthio and alkanoyl each with 1 to 4 carbon atoms or from such groups as nitro, cyano, phenyl and tolyl, Y is oxygen or sulfur and R1 and R2 are such groups as C5-C12 alkyl or alkenyl, alkinyl, cycloalkyl each wlth 4 to 12 carbon atoms or C7-C14 aralkyl.

420024

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