A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2706926
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to B7H4 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vec-tors, host cells and methods for expressing the antibodies of this disclosure are also provided, hnmunoconjugates, including anti-body-drug conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
L'invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains qui se fixent de manière spécifique à B7H4 avec une grande affinité. L'invention concerne également les molécules d'acide nucléique codant les anticorps de l'invention, les vecteurs d'expression, les cellules hôtes ainsi que des procédés d'expression des anticorps de l'invention. L'invention concerne également des immunoconjugués, notamment des conjugués anticorps-médicaments, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de l'invention. L'invention concerne enfin, des méthodes de traitement du cancer.
Cardarelli Josephine M.
Chen Bingliang
King David J.
Rao-Naik Chetana
Terrett Jonathan A.
Bristol-Myers Squibb Company
Smart & Biggar
LandOfFree
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