Anti-bcma antibodies

Details Anti-bcma antibodies Anti-bcma antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2754938

This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naïve B cells, plasma cells, and/or memory B cells. The invention further provides methods for depleting naïve B cells, plasma cells, and memory B cells, and for treating B cell-related disorders, including lymphomas and autoimmune diseases.

Cette invention concerne des anticorps reconnaissant l'antigène de maturation des lymphocytes B (BCMA) et se fixant aux lymphocytes B naïfs, aux plasmocytes et/ou aux lymphocytes B mémoire. L'invention concerne par ailleurs des méthodes de réduction des lymphocytes B naïfs, de plasmocytes et/ou de lymphocytes B mémoire, et des méthodes de traitement des affections associées aux lymphocytes B, notamment les lymphomes et les maladies auto-immunes.

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