C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2760642
Provided is an anti-cadherin antibody having strong antibody-dependent cytotoxicity. The anti-cadherin antibody recognizes cadherin domain 4 (EC4), cadherin domain (EC5), or a domain upstream from EC1, and has an antibody-dependent cytotoxicity of 30% or greater at an antibody concentration of 1 µg/mL.
L'invention concerne un anticorps anti-cadhérine présentant une forte cytotoxicité dépendant de l'anticorps. L'anticorps anti-cadhérine reconnaît le domaine cadhérine 4 (EC4) ou le domaine cadhérine (EC5) en amont de EC1 et présente une cytotoxicité dépendant de l'anticorps de 30% ou plus pour une concentration d'anticorps de 1 µg/mL.
Aburatani Hiroyuki
Ishii Keisuke
Katsumi Keiko
Kayukawa Yoko
Kouda Katsushi
Dennison Associates
Perseus Proteomics Inc.
The University Of Tokyo
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