C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01) C07D 257/00 (2006.01) C07F 11/00 (2006.01) C07F 15/06 (2006.01)
Patent
CA 2435653
This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.
Cette invention se rapporte à une classe d'hétérocycles et à leurs complexes métalliques et, plus particulièrement, à l'utilisation de ces composés dans la préparation de promédicaments ou comme promédicaments pouvant être activés dans des conditions hypoxiques par des enzymes ou par rayonnement ionisant thérapeutique, dans le traitement du cancer. Cette invention concerne également l'utilisation de ces hétérocycles et des complexes métalliques correspondants dans la préparation de médicaments, ainsi que des compositions contenant ces hétérocycles ou leurs complexes métalliques et des procédés de préparation de ces composés.
Atwell Graham John
Denny William Alexander
Milbank Jared Bruce John
Stevenson Ralph James
Ware David Charles
Auckland Uniservices Limited
Sim & Mcburney
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