Anti-cancer agent

Details Anti-cancer agent Anti-cancer agent

A - Human Necessities

61

K

A61K 38/18 (2006.01)

Patent

CA 2235805

The invention relates to an anti-cancer agent containing a-chain protein (.alpha.-fragment) of HGF (hepatocyte growth factor) as an active ingredient. The active ingredient of .alpha.-fragment has a specific suppressing effect on invasion and metastasis of cancer cells such as gallbladder cancer, lung cancer and other, which are highly metastatic and result in a high mortality. Therefore, the agent of the invention is used in treatment and prevention of cancer as an anti-cancer agent, and is extremely useful clinically.

L'invention concerne un agent antitumoral contenant la protéine chaînes alpha (fragment alpha ) d'un facteur de croissance des hépatocytes (HGF), en tant que composant actif. Le fragment alpha , composant actif fait office d'antagoniste inhibant spécifiquement la capacité de cellules cancéreuses à envahir des tissus et à former des métastases à l'aide du HGF. Ce médicament est particulièrement efficace pour inhiber l'invasion et la métastase de cellules cancéreuses, par exemple pour empêcher les cancers de la vésicule biliaire et des poumons, où la tendance à former des métastases est très forte et la mortalité très élevée. On utilise ce médicament antitumoral très utile pour le traitement clinique de cancers, leur prévention, etc.

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