A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/55 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2455883
The invention provides inhibitors of matrix metalloproteinase that are useful as anti-tumor agents and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering, and wound dressings that inhibit expression of vascular endothelial growth factor and encourage healing.
L'invention concerne des inhibiteurs des métalloprotéinases de matrice, utilisés comme agents antinéoplasiques et destinés à traiter des plaies. Les inhibiteurs sont des peptides pourvus de séquences afférentes aux régions de clivage des formes de proenzymes des métalloprotéinases de matrice. Les inhibiteurs de peptides de cette invention peuvent être préparés dans des compositions thérapeutiques, des lotions, des crèmes, des revêtements cutanés, et des pansements pour blessures qui inhibent l'expression du facteur de croissance endothéliale vasculaire et favorisent la guérison.
Quirk Stephen
Weart Ilona F.
Borden Ladner Gervais Llp
Kimberly-Clark Worldwide Inc.
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