A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/675 (2006.01) A61K 31/122 (2006.01) A61K 31/196 (2006.01) A61K 31/222 (2006.01) A61K 31/405 (2006.01) A61K 31/573 (2006.01) A61K 31/663 (2006.01) A61K 45/06 (2006.01) A61P 3/04 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2472578
The present invention relates to the surprising discovery that the combination of several agents, each well known for its established role in treatinf cancer, inflammation, hemostasis, bone resorption or serving as a solubilizing vehicle, results in a synergistic anti-cancer composition. Furthermore, the combination of at least three agents allows the cytotoxic agent, such as cyclophosphamide, to be used at a lower dosage than when administered alone. One predidted consequence of this treatment, therefore, is a highly desirable reduction in toxic side effects due to the cytotoxic agent.
L'invention concerne une découverte étonnante, à savoir que la combinaison de plusieurs agents, chacun bien connu pour son rôle établi au niveau du traitement du cancer, des inflammations, de l'hémostase, de la résorption osseuse, ou en tant que véhicule solubilisant, produit une composition synergétique anticancéreuse. En outre, la combinaison d'au moins trois agents permet d'utiliser l'agent cytotoxique, par exemple le cyclophosphamide, à un dosage plus faible que lorsqu'il est administré seul. En conséquence, ce traitement a notamment pour conséquence prévisible une diminution particulièrement recherchée des effets toxiques secondaires dus à l'agent cytotoxique.
Ben-Sasson Shmuel A.
Tsirulnikov Lilia
Vainstein Vladimir
Children's Medical Center Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Tiltan Pharma Ltd.
Yissum Research Development Company Of The Hebrew University Of
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