C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/208, 260/236
C07C 291/04 (2006.01) A61K 31/135 (2006.01) A61K 31/395 (2006.01) C07D 295/24 (2006.01) C09B 1/515 (2006.01)
Patent
CA 2038934
Compounds of formula (I) Image in which R1, R2, R3 and R4 are each separately selected from hydrogen, X, NH-A-NHR and NH-A-N(0)R'R" wherein X is hydroxy, halogeno, amino, C1-4 alkoxy or C2-8 alkanoyloxy, A is a C2-4 alkylene group with a chain length between NH and NHR or N(0)R'R" of at least 2 carbon atoms and R, R' and R" are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R" together are a C2-6 alkylene group which with the nitrogen atom to which R' and R" are attached forms a heterocyclic group having 3 to 7 atoms in the ring, but with the proviso that at least one of R1 to R4 is a group NH-A-N(O)R'R", and physiologically acceptable salts thereof are of value in the treatment of cancer.
Btg International Limited
Fetherstonhaugh & Co.
The National Research Development Corporation
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