Anti-cancer compounds

Details Anti-cancer compounds Anti-cancer compounds

C - Chemistry, Metallurgy

07

C

C07C 291/04 (2006.01) A61K 31/13 (2006.01) A61K 31/395 (2006.01) C07C 251/86 (2006.01) C07D 233/54 (2006.01) C07D 233/88 (2006.01) C07D 277/22 (2006.01) C07D 277/50 (2006.01) C07D 295/24 (2006.01)

Patent

CA 2108256

2108256 9218469 PCTABS00016 Compounds of formula (I), in which R1 is CH=CHR, CH=NNHR, CH=N-A-N(O)R'R'' or CH2-NH-A-N(O)R'R'' and R2 is separately selected from hydrogen, CH=CHR, CH=NNHR, CH=N-A-(O)R'R'' and CH2-NH-A-N(O)R'R'', wherein A is a C2-4 alkylene group with a chain length between N or NH and N(O)R'R'' of at least 2 carbon atoms, R is a thiazolyl or imidazolyl group in which the tertiary nitrogen atom is in N-oxide form, and R' and R'' are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C3-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R'' together are a C2-6 alkylene group which with the nitrogen atom to which R' and R'' are attached forms a heterocyclic group having 3 to 7 atoms in the ring, and R3, R4, R5 and R6 are each separately selected from hydrogen, hydroxy, halogeno, amino, C1-4 alkoxy and C2-8 alkanoyloxy, and physiologically acceptable salts thereof are of value in the treatment of cancer.

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