Anti-cancer compounds

Details Anti-cancer compounds Anti-cancer compounds

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/04 (2006.01) C07D 239/90 (2006.01) C07D 239/95 (2006.01)

Patent

CA 2106583

2106583 9216512 PCTABS00016 Quinazolines of formula (I), wherein R1 is hydrogen or amino, or R1 is alkyl, alkoxy or alkylthio each of up to 6 carbon atoms; or R1 is aryl or aryloxy each of up to 10 carbon atoms; or R1 is halogeno, hydroxy or mercapto; or R1 is alkyl of up to 3 carbon atoms which bears one or more substituents selected from halogeno, hydroxy and alkanoylamino each of up to 6 carbon atoms; or R1 is alkoxy of up to 3 carbon atoms which bears one or more substituents selected from hydroxy and alkoxy of up to 6 carbon atoms; wherein R2 is hydrogen or alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, mercaptoalkyl, alkylthioalkyl, halogenoalkyl, cyanoalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkanoylalkyl, carboxyalkyl, carbamoylalkyl or alkanoyl each of up to 6 carbon atoms; wherein Ar is phenylene or heterocyclene which is unsubstituted or which bears one or more substituents selected from halogeno, cyano, nitro, hydroxy, amino and carbamoyl and alkyl, alkoxy, halogenoalkyl, alkanoylamino, alkylthio and alkoxycarbonyl each of up tp 6 carbon atoms;R3 is the residue of a dipeptide in which the first, N-terminal amino acid residue thereof attached to the carbonyl group of COR3 is an L- or D-amino acid residue -NHCH(CO2H)-A-CO- in which A is an alkylene group of up to 6 carbon atoms and the second amino acid residue is of an .alpha.-amino acid which has the D-configuration at its asymmetric .alpha.-carbon atom; wherein R4 is hydrogen or alkyl of up to 4 carbon atoms; wherein R5 is hydrogen or alkyl of up to 4 carbon atoms; and wherein each of R6, R7 and R8 is hydrogen or alkyl or alkoxy each of up to 4 carbon atoms; or is halogeno; or a pharmaceutically-acceptable salt, ester or amide thereof are of therapeutic value, particularly in the treatment of cancer.

Affiliated with

Also associated with

Rating

Anti-cancer compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-cancer compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-cancer compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1611754