Anti-cancer dna vaccine employing plasmids encoding mutant...

Details Anti-cancer dna vaccine employing plasmids encoding mutant... Anti-cancer dna vaccine employing plasmids encoding mutant...

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61K 31/713 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2595726

Novel nucleic acid vectors comprising sequences encoding (a) calreticulin or a domain thereof, and (b) an antigen, such as human papillomavirus oncoproteins E7 or E6 in detoxified form, are disclosed, as are methods for using such vectors to induce antigen-specific immune responses and to treat or prevent development of tumors.

L'invention porte sur de nouveaux vecteurs d'acides nucléiques comprenant des séquences codant (a) la calréticuline ou un domaine de celle-ci et (b) un antigène tel que les oncoprotéines E7 or E6 du papillomavirus humain sous forme détoxifiée, ainsi que sur des méthodes d'utilisation de ces vecteurs afin d'induire des réponses immunes spécifiques d'un antigène et de traiter ou prévenir le développement de tumeurs.

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