Anti-cancer quinazoline derivatives

Details Anti-cancer quinazoline derivatives Anti-cancer quinazoline derivatives

C - Chemistry, Metallurgy

07

D

260/254, 530/5.0

C07D 239/94 (2006.01) C07D 205/04 (2006.01) C07D 239/95 (2006.01)

Patent

CA 1184900

ABSTRACT Quinazoline derivatives of formula: Image (I) wherein R represents: 1) a straight or branched chain unsaturated hydrocarbon group, or 2) a straight or branched chain saturated or unsaturated hydrocarbon group which is substituted by at least one: heteroatom, the or each heteroatom being halogeno when R is a C1 hydrocarbon group: or saturated carbocyclic group, or group containing at least one heteroatom, the or each heteroatom being 0, N or S when R contains a cyclic group, and n is 0 or an integer of 1-4; X or, when n is an integer of at least 2, each X independently, represents a halogeno, C1-C4 alkyl, aryl or aralkyl group or a group including at least one heteroatom; and Y represents a group of formula:- a) Image b) Image or c) wherein m ? 1 (poly-L-glutamates); and the pharmaceutically acceptable salts and esters thereof, which are suitable as anti-cancer agents.

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