Anti-cancer virus desensitization method

A - Human Necessities – 61 – K

Patent

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A61K 39/17 (2006.01)

Patent

CA 2519337

A mammalian subject having a tumor is treated by a method comprising administering to the subject an amount of a Newcastle disease virus effective to treat the subject, wherein the virus is administered to the subject in one or more cycles; at least one cycle comprises administering sequentially one or more desensitization doses of the followed by one or more escalated doses of the virus to the subject; the amount of the virus in each escalated dose is higher than the amount of virus in each desensitization dose; and the first escalated dose is administered from 18 to 36 hours after the first desensitization dose.

Selon l'invention, un sujet mammifère présentant une tumeur est traité à l'aide d'une méthode comprenant l'administration à un sujet d'une quantité efficace du virus de la maladie de Newcastle pour traiter le sujet, le virus étant administré au sujet sur un ou plusieurs cycles. Au moins un cycle comprend l'administration séquentielle d'une ou plusieurs doses de désensibilisation suivies par des doses intensifiées du virus au sujet. La quantité de virus dans chaque dose intensifiée est plus élevée que la quantité de virus dans chaque dose de désensibilisation et la première dose intensifiée est administrée entre 18 et 36 heures après la première dose de désensibilisation.

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