Anti-ccp and antinuclear antibodies in diagnosis of...

G - Physics – 01 – N

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G01N 33/564 (2006.01)

Patent

CA 2623167

The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in the differential diagnosis of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample both the concentration of anti-CCP and of antinuclear antibodies (ANA) correlating the concentrations determined to the diagnosis of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and ANA and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti- CCP and ANA in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.

La présente invention concerne un procédé contribuant à l~évaluation de la polyarthrite rhumatoïde. Ce procédé est plus particulièrement utilisé dans le diagnostic différentiel de la polyarthrite rhumatoïde in vitro. Ce procédé est par exemple pratiqué au moyen de l~analyse de marqueurs biochimiques, qui comprend la mesure, dans un échantillon, à la fois de la concentration d~anticorps anti-CCP et d~anticorps antinucléaires (AAN), en corrélant les concentrations déterminées au diagnostic de la polyarthrite rhumatoïde. Dans un procédé selon cette invention destiné à encore améliorer l~évaluation de la PR, les taux d~un ou de plusieurs marqueurs complémentaires peuvent être déterminés en plus de celui des anti-CCP et les AAN, et être corrélés à l~absence ou à la présence de PR. Cette invention concerne également l~utilisation d~un groupe marqueur comprenant des anti-CCP et des AAN dans le diagnostic de la polyarthrite rhumatoïde. L~invention décrit en outre un kit permettant de réaliser le procédé selon l~invention.

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