Anti-ccr5 antibody

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 31/18 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2476901

The invention is directed an anti-CCR5 antibody which comprises (i) two light chains, each light chain comprising the expression product of a plasmid designated pVK:HuPRO140-VK (ATCC Deposit Designation PTA-4097), and (ii) two heavy chains, each heavy chain comprising an expression product of either a plasmid designated pVg1:HuPRO140 HG2-VH (ATCC Deposit Designation PTA-4098) or a plasmid designated pVgl:HuPR0140 (mutB+D+I)-VH (ATCC Deposit Designation PTA- 4099) or a fragment thereof which binds to CCR5 on the surface of a human cell.

L'invention concerne un anticorps anti-CCR5 constitué de (i) deux chaînes légères comprenant le produit d'expression d'un plasmide désigné pVK:HuPRO140-VK (numéro de dépôt ATCC: PTA-4097), et de (ii) deux chaînes lourdes, chaque chaîne lourde comprenant un produit d'expression soit d'un plasmide désigné pVg1:HuPRO140 HG2-VH (numéro de dépôt ATCC: PTA-4098), soit d'un plasmide désigné pVgl:HuPR0140 (mutB+D+I)-VH (numéro de dépôt ATCC: PTA-4099), soit d'un fragment de ce plasmide qui se lie au récepteur CCR5 sur la surface d'une cellule humaine.

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