Anti-ccr7 receptor antibodies for the treatment of cancer

Details Anti-ccr7 receptor antibodies for the treatment of cancer Anti-ccr7 receptor antibodies for the treatment of cancer

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2614080

Antibodies, or antigen-binding fragment thereof, which bind to a CCR7 receptor are capable of selectively killing, impairing migration and/or blocking dissemination of tumour cells expressing a CCR7 receptor. Use of said antibodies for killing or for inducing apoptosis of said tumour is disclosed, thus providing an alternative therapy for treatment of cancer which tumour cells express a CCR7 receptor.

Selon l'invention, des anticorps ou des fragments de liaison à l'antigène de ceux-ci, qui se lient à un récepteur CCR7, sont capables de détruire, d'empêcher la migration et/ou de bloquer la dissémination, de manière sélective, de cellules tumorales qui expriment un récepteur CCR7. L'invention a également pour objet l'utilisation de ces anticorps pour détruire ou pour induire l'apoptose des cellules tumorales, ce qui permet d'obtenir une thérapie alternative pour traiter un cancer dont les cellules tumorales expriment un récepteur CCR7.

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