C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/06 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2429467
Based on a finding that the domain ranging from the 269- to 315-positions of human DC14 represented by SEQ ID NO:1 is a site capable of interacting with another protein, an antibody which specifically recognizes an epitope containing a part of this domain is provided. This antibody can inhibit the interaction between human CD14 and another protein and thus suppress cell activation. Moreover, hybridomas producing the above antibody or its fragment; a peptide containing the amino acids in the domain as specified above; a method of constructing an antibody with the use of this peptide as an immunogen; and a method of screening a remedy for sepsis involving the step of bringing a test substance into contact with CD14 and TLR; are provided.
L'invention est basée sur la découverte que le domaine s'étendant entre les positions 269 à 315 de CD14 humain représenté par SEQ ID NO:1 est un site capable d'exercer une interaction avec une autre protéine, anticorps reconnaissant de façon spécifique un déterminant antigénique contenant une partie de ce domaine. Cet anticorps peut inhiber l'interaction entre CD14 humain et une autre protéine et, de ce fait, supprimer l'activation cellulaire. L'invention concerne, de plus, des hybridomes produisant cet anticorps ou son fragment, un peptide contenant les acides aminés du domaine spécifié, un procédé de construction d'un anticorps au moyen de ce peptide en tant qu'immunogène et un procédé de criblage d'un médicament anti-infectieux consistant à mettre en contact une substance d'essai avec CD14 et TLR.
Furusako Shoji
Mori Sadao
Shirakawa Kamon
Mochida Pharmaceutical Co. Ltd.
Smart & Biggar
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