Anti-cd147 antibodies, methods, and uses

Details Anti-cd147 antibodies, methods, and uses Anti-cd147 antibodies, methods, and uses

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2737519

The present invention provides antibodies immunospecific for human CD 147 capable of blocking bioactivity of CD 147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD 147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.

La présente invention concerne des anticorps immunospécifiques de CD147 humaine capables de bloquer la bioactivité de CD147 associée à une néoplasie comme la stimulation des MMP des fibroblastes par les cellules tumorales, la libération du VEGF, et la promotion de langiogenèse. Les anticorps de la présente invention sont utiles pour traiter une néoplasie ainsi que les maladies dans lesquelles lactivité de CD 147 joue un rôle pathogène, telles que des maladies du système oculaire, pulmonaire, et cardiovasculaire.

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