Anti-cd154 antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2575838

The present invention provides peptides, and fragments thereof, and antibodies, or fragments thereof comprising the same, wherein the peptide comprises at least one amino acid substitution compared to wild type 5c8 antibody. The present invention also provides compositions and methods of treating CD154-related diseases or disorders in a subject.

L'invention concerne des peptides et des fragments de ceux-ci, et des anticorps ou des fragments de ceux-ci comprenant les peptides. Le peptide comprend au moins une substitution d'acide aminé par rapport à l'anticorps 5c8 de type sauvage. L'invention concerne aussi des compositions et des méthodes de traitement de maladies ou de troubles liés à CD154 chez un sujet.

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