Anti-cd16 binding molecules

Details Anti-cd16 binding molecules Anti-cd16 binding molecules

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2609593

The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. Fc.gamma.RIIIA), and in particular binding molecules that specifically bind the A form Fc.gamma.RIII but do not bind to the B form of Fc.gamma.RIII, as well as to the use of such binding molecules in the diagnosis and treatment of disease. The invention further extends to polynucleotides encoding such binding molecules, host cells comprising such polynucleotides and methods of producing binding molecules of the invention using such host cells.

La présente invention concerne des molécules de liaison qui se lient de manière spécifique au récepteur gamma humain du fragment Fc exprimé à la surface de cellules tueuses naturelles (NK) et de macrophages (c.-à-d. Fc?RIIIA). Elle concerne en particulier des molécules de liaison qui se lient de manière spécifique à la forme A de Fc?RIII mais ne se lient pas à la forme B de Fc?RIII; ainsi que l'utilisation desdites molécules de liaison dans le diagnostic et le traitement de maladies. L'invention concerne en outre des polynucléotides codant les molécules de liaison, des cellules hôtes comprenant ces polynucléotides, et des méthodes de production de molécules de liaison utilisant ces cellules hôtes.

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