Anti-cd20 antibody-drug conjugates for the treatment of...

A - Human Necessities – 61 – K

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Details

A61K 47/48 (2006.01) A61K 31/40 (2006.01) A61K 31/7048 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2494104

The present invention relates to methods and compositions for the treatment of CD20-expressing cancers and immune disorders involving CD20-expressing cells. The present methods comprise administering to a subject an anti CD20 antibody- drug conjugate that has a high potency and/or is capable of internalizing into CD20-expressing cells. The present invention further provides pharmaceutical compositions and kits comprising such conjugates. The present invention yet further provides methods of and compositions relating to combination therapy of cancer and immune disorders involving CD20-expressing cells using the anti- CD20 antibody-drug conjugates of the invention.

L'invention concerne des procédés et des compositions destinés au traitement de cancers exprimant CD-20 et de troubles immunitaires impliquant des cellules exprimant CD-20. Ces procédés consistent à administrer au patient un conjugué anticorps CD-20-médicament à fort pouvoir et/ou capable de se transformer en cellules exprimant CD-20. L'invention concerne en outre des procédés et des compositions se rapportant à une thérapie de combinaison de cancers et troubles immunitaires impliquant des cellules exprimant CD-20 à l'aide des conjugués anticorps CD-20-médicament.

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