C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) A61P 7/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2603414
Disclosed is a monoclonal antibody capable of inducing a specific biological reaction through the binding of the monoclonal antibody to a CD-20 antigen on the surface of a cell. A monoclonal antibody having a high binding affinity to an extracellular epitope of a CD-20 antigen and also having biological activities including a cell growth inhibitory activity is cloned. The monoclonal antibody is chimerized or humanized to develop a therapeutic agent for a disease in which B cells are involved.
L'invention porte sur un anticorps monoclonal capable d'induire une réaction biologique spécifique dans la liaison d'un anticorps monoclonal à un antigène CD-20 sur la surface d'une cellule. L'invention porte également sur le clonage d'un anticorps monoclonal ayant une haute affinité de liaison avec un épitope extracellulaire d'un antigène CD-20 et ayant également des activités biologiques telles qu'une activité inhibitrice de la prolifération cellulaire. L'anticorps monoclonal est chimérisé et humanisé de façon à mettre au point un agent thérapeutique destiné à traiter les maladies dans lesquelles sont impliquées les cellules B.
Nakamura Tetsuo
Numazaki Masanori
Padlan Eduardo A.
Usuda Sadakazu
Biomedics Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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