C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 16/28 (2006.01) C07K 17/10 (2006.01) C12N 5/02 (2006.01) G01N 33/531 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2164646
The invention describes the use of novel aminodextran compounds containing about 5-20 % by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferation of selected mammalian cells. Specific examples are given using an anti- CD3 monoclonal antibody conjugated to aminodextrans containing about 5 % and 16 %, respectively, by weight amine groups as an agent for inducing the activation and proliferation of T cells.
L'invention se rapporte à l'utilisation de nouveaux composés d'aminodextrane, contenant environ 5 à 20 % en poids de groupes amines, pour lier une pluralité d'anticorps monoclonaux. Les composés à base d'aminodextrane/anticorps obtenus peuvent être utilisés pour induire l'activation et la prolifération de cellules de mammifère choisies. Des exemples spécifiques sont cités, lesquels comprennent l'utilisation d'un anticorps monoclonal anti-CD3, conjugué à deux aminodextranes contenant respectivement environ 5 à 16 % en poids de groupes amines, comme agent permettant d'induire l'activation et la prolifération de lymphocytes T.
Bolton Wade E.
Healy Cynthia G.
Kenyon Norma Sue
Maples John A.
Siiman Olavi
Coulter Corporation
Macera John Stephen
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