C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) C12N 5/09 (2010.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) C12Q 1/04 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2504818
The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of said antibodies, humanized and resurfaced versions of said antibodies, functional equivalents and improved versions of said antibodies, immunoconjugates and compositions comprising said antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding the antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing the antibodies.
La présente invention concerne des anticorps se liant à CD33. Cette invention concerne plus particulièrement des anticorps anti-CD33, des fragments et homologues de ces anticorps, des versions humanisées et "resurfacées" desdits anticorps, des équivalents fonctionnels et versions améliorées de ces anticorps, des immunoconjugués et compositions contenant lesdits anticorps ainsi que l'utilisation de ces derniers dans des applications diagnostiques, thérapeutiques et de recherche. Cette invention se rapporte également à un polynucléotide codant pour ces anticorps, des vecteurs contenant ces polynucléotides, des cellules hôtes transformées à l'aide desdits polynucléotides ainsi que des procédés de production desdits anticorps.
Hoffee Mary G.
Lutz Robert J.
Tavares Daniel
Gowling Lafleur Henderson Llp
Immunogen Inc.
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