Anti-cd38 human antibodies and uses therefor

Details Anti-cd38 human antibodies and uses therefor Anti-cd38 human antibodies and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01)

Patent

CA 2555185

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated with malignancies. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use therefore.

L'invention concerne des régions de liaison aux antigènes recombinantes et des anticorps et des fragments fonctionnels renfermant de telles régions spécifiques pour CD38 jouant un rôle intégral dans divers troubles ou états. Ces anticorps peuvent être, par conséquent, utilisés pour traiter, par exemple, des malignités hématologiques, telles que le myélome multiple. Les anticorps selon l'invention peuvent également être utilisés dans le domaine du diagnostic, ainsi que pour la détermination du rôle de CD38 dans l'évolution de troubles associés à des malignités. L'invention concerne également des séquences d'acides nucléiques codant lesdits anticorps, des vecteurs renfermant celles-ci, des compositions pharmaceutiques et des kits dotés de modes d'utilisation. L'invention concerne également des épitopes isolés de CD38 et des procédés d'utilisation de ceux-ci.

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