Anti-cd40 antibodies and uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/00 (2006.01) C07K 14/725 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2754862

The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

La présente invention concerne des compositions et des procédés pour l'expression, la sécrétion et l'utilisation de nouvelles compositions pour utilisation en tant que, par exemple, vaccins et vecteurs de délivrance d'antigène, pour délivrer des antigènes à des cellules de présentation d'antigène. Dans un mode de réalisation, le vecteur est un anticorps anti-CD40, ou des fragments de celui-ci, et un ou plusieurs peptides antigéniques liés à l'anticorps anti-CD40 ou des fragments de celui-ci, comprenant des anticorps humanisés.

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