C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 36/36 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 37/00 (2006.01) C07K 14/415 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/29 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2294223
An immunotoxin molecule is described which comprises an antibody specific for human CD40L antigen located on the surface of a human cell, coupled to a toxin molecule or active fragment thereof, wherein the binding of the immunotoxin to the CD40L molecule results in the killing of the CD40L expressing cell. The toxin molecule is especially a type-1 ribosome inactivating protein, or an active fragment thereof. The immunotoxin can be used for the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus, or T-cell malignancies.
Molécule d'immunotoxine comprenant un anticorps spécifique pour l'antigène CD40L humain situé sur la surface d'une cellule humaine, couplé à une molécule de toxine ou à un de ses fragments actifs, la fixation de l'immunotoxine à la molécule de CD40L provoquant la destruction de la cellule exprimant CD40L. Cette molécule de toxine est, en particulier, une protéine inactivant un ribosome de type-1 ou un fragment actif de ladite protéine. On peut utiliser cette immunotoxine afin de traiter des maladies auto-immunes, telles que la sclérose en plaques, la polyarthrite rhumatoïde et le lupus érythémateux disséminé ou des malignités de lymphocytes T.
de Boer Mark
Den Hartog Marcel Theodorus
Fetherstonhaugh & Co.
Pangenetics B.v.
LandOfFree
Anti-cd40l immunotoxins for the treatment of diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-cd40l immunotoxins for the treatment of diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-cd40l immunotoxins for the treatment of diseases will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1383491