Anti-cd40l immunotoxins for the treatment of diseases

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A61K 36/36 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 37/00 (2006.01) C07K 14/415 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/29 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2294223

An immunotoxin molecule is described which comprises an antibody specific for human CD40L antigen located on the surface of a human cell, coupled to a toxin molecule or active fragment thereof, wherein the binding of the immunotoxin to the CD40L molecule results in the killing of the CD40L expressing cell. The toxin molecule is especially a type-1 ribosome inactivating protein, or an active fragment thereof. The immunotoxin can be used for the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus, or T-cell malignancies.

Molécule d'immunotoxine comprenant un anticorps spécifique pour l'antigène CD40L humain situé sur la surface d'une cellule humaine, couplé à une molécule de toxine ou à un de ses fragments actifs, la fixation de l'immunotoxine à la molécule de CD40L provoquant la destruction de la cellule exprimant CD40L. Cette molécule de toxine est, en particulier, une protéine inactivant un ribosome de type-1 ou un fragment actif de ladite protéine. On peut utiliser cette immunotoxine afin de traiter des maladies auto-immunes, telles que la sclérose en plaques, la polyarthrite rhumatoïde et le lupus érythémateux disséminé ou des malignités de lymphocytes T.

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