C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 16/24 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2583208
Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, systatic or immunosuppressive without conjugation to a therapeutic agenst, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.
L'invention concerne des agents de liaison CD70, du type anticorps anti-CD70 et dérivés, qui induisent une réponse cytotoxique, cytostatique ou immunosuppresseuse, sans conjugaison avec un agent thérapeutique, et des compositions pharmaceutiques et des kits renfermant l'anticorps ou le dérivé. On décrit aussi des procédés pour le traitement et la prévention de cancers et de troubles immunologiques à expression CD70, qui consistent à administrer l'agent de liaison CD70 considéré.
Law Che-Leung
Mcearchern Julie
Wahl Alan F.
Seattle Genetics Inc.
Smart & Biggar
LandOfFree
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