A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2516455
Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
L'invention concerne des anticorps anti-CD70 et des dérivés desdits anticorps conjugués à des agents cytotoxiques, immunosuppresseurs ou à d'autres agents thérapeutiques. L'invention concerne également des compositions et des kits pharmaceutiques contenant lesdits conjugués de médicaments anticorps et dérivés d'anticorps. L'invention concerne également des méthodes de traitement des cancers et des troubles immunitaires à expression CD70. Lesdites méthodes consistent à administrer à un sujet les compositions pharmaceutiques selon l'invention.
Law Che-Leung
Pestano Linda A.
Scholler Nathalie
Wahl Alan F.
Fetherstonhaugh & Co.
Seattle Genetics Inc.
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