C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/79 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2612486
The present invention provides novel anti-CD71 monoclonal antibodies, in particular mouse-human chimeric anti-CD71 monoclonal antibodies, advantageously associated to effector cells for triggering ADCC mechanisms. Anti-CD71 antibodies, as well as pharmaceutical compositions containing them, are useful for inhibiting proliferation and/or killing malignant tumour cells, especially metastatic cutaneous and uveal melanoma cells.
L'invention porte sur de nouveaux anticorps monoclonaux anti-CD71 et en particulier sur des anticorps monoclonaux anti-CD71 chimères souris /homme avantageusement associés à des cellules effectrices pour déclencher les mécanismes ADCC. Les anticorps anti-CD71 ainsi que des préparations pharmaceutiques les contenant s'avèrent utiles pour inhiber la prolifération des cellules tumorales malignes et les détruire, spécialement les cellules de métastases cutanées et de mélanomes de l'uvée.
Bensussan Armand
Boumsell Laurence
Kadouche Jean
Institut National de La Sante Et de La Recherche Medicale
Monoclonal Antibodies Therapeutics
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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